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Will my puppy have a reaction to vaccines? The truth is that some animals will indeed have systemic reactions, including low fever or muscle aches and pains. This reaction, however, is more likely to occur in young pups and smaller breeds of dogs (tiny terriers).
A vaccine may cause a decrease in appetite and an increase in naptime (your pup may sleep for up to 24 to 48 hours following a vaccination). Sometimes, a dog may have a more severe reaction like hives, swelling of the face, vomiting, or diarrhea.
Want to prevent a severe reaction? Give your pet an antihistamine at the time of vaccination. If your dog has a history of strong reactions, don't forfeit all future vaccinations, however, warn your vet and discuss possible options.